A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regions

A. Hari Dass, Shantala; McCracken, Kathryn; Pokhvisneva, Irina; M. Chen, Lawrence; Garg, Elika; T. T. Nguyen, Thao; Wang, Zihan; Barth, Bárbara; Yaqubi, Moein; M. McEwen, Lisa; L. MacIsaac, Julie; Diorio, Josie; S. Kobor, Michael; J. O’Donnell, Kieran; J. Meaney, Michael; Pelufo Silveira, Patrícia

doi:10.1016/j.ebiom.2019.03.051

Public

A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regions

Published in EBioMedicine • Mar 26, 2019

Authors:

Shantala A. Hari Dass

Kathryn McCracken

Irina Pokhvisneva

Abstract

BACKGROUND: Activation of brain insulin receptors modulates reward sensitivity, inhibitory control and memory. Variations in the functioning of this mechanism likely associate with individual differences in the risk for related mental disorders (attention deficit hyperactivity disorder or ADHD, addi...

Subject

Endophenotype

Brain function

Biology

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