Metformin Inhibits the NLRP3 Inflammasome via AMPK/mTOR-dependent Effects in Diabetic Cardiomyopathy

Yang, Fan; Qin, Ying�; Wang, Yueqiu; Meng, Songyan; Xian, Huimin; Che, Hui; Lv, Jie; Li, Yang; Yu, Yahan; Bai, Yunlong; Wang, Lihong

doi:10.7150/ijbs.29680

Public

Metformin Inhibits the NLRP3 Inflammasome via AMPK/mTOR-dependent Effects in Diabetic Cardiomyopathy

Published in International Journal of Biological Sciences • Jan 1, 2019

Authors:

Fan Yang

Ying� Qin

Yueqiu Wang

Abstract

Metformin is a widely used antidiabetic drug for type 2 diabetes that can play a cardioprotective role through multiple pathways. It is a recognized agonist of AMP-activated protein kinase (AMPK) that blocks mitochondrial complex I. The NLRP3 inflammasome has been demonstrated to be activated in dia...

Subject

Metformin

AMPK

Diabetic cardiomyopathy

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