Fine-scale haplotype mapping of MUT, AACS, SLC6A15 and PRKCA genes indicates association with insulin resistance of metabolic syndrome and relationship with branched chain amino acid metabolism or regulation.

Sara, Haydar,; Florin, Grigorescu,; Mădălina, Vintilă,; Yannick, Cogne,; Corinne, Lautier,; Yildiz, Tutuncu,; Jean Frederic, Brun,; Jean Marie, Robine,; Michel, Pugeat,; Christophe, Normand,; Patrick, Poucheret,; Monica Livia, Gheorghiu,; Carmen, Georgescu,; Corin, Badiu,; Nicoleta, Băculescu,; Eric, Renard,; Dorina, Ylli,; Stephanie, Badiou,; Thibault, Sutra,; Jean Paul, Cristol,; Jacques, Mercier,; Ramon, Gomis,; Josep Maria, Macias,; Serghey, Litvinov,; Elza, Khusnutdinova,; Catalina, Poiana,; Renato, Pasquali,; Davide, Lauro,; Giorgio, Sesti,; Sabrina, Prudente,; Vincenzo, Trischitta,; Agathocles, Tsatsoulis,; Sonia, Abdelhak,; Abdelhamid, Barakat,; Akila, Zenati,; Agron, Ylli,; Ilhan, Satman,; Timo, Kanninen,; Yves, Rinato,; Sasa, Missoni,

doi:10.1371/journal.pone.0214122

Public

Fine-scale haplotype mapping of MUT, AACS, SLC6A15 and PRKCA genes indicates association with insulin resistance of metabolic syndrome and relationship with branched chain amino acid metabolism or regulation.

Published in PloS one • Jan 1, 2019

Authors:

Haydar, Sara

Grigorescu, Florin

Vintilă, Mădălina

Abstract

Branched chain amino acids (BCAA) are essential elements of the human diet, which display increased plasma levels in obesity and regained particular interest as potential biomarkers for development of diabetes. To define determinants of insulin resistance (IR) we investigated 73 genes involved in BC...

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Adult

Amino Acid Transport Systems

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