Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity

M. Habib, Abdella; L. Okorokov, Andrei; N. Hill, Matthew; Brás, José; Lee, Man-Cheung; Li, Shengnan; J. Gossage, Samuel; van Drimmelen, Marie; Morena, Maria; Houlden, Henry; D. Ramirez, Juan; Bennett, David; Srivastava, Devjit; J. Cox, James

doi:10.1016/j.bja.2019.02.019

Public

Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity

Published in British Journal of Anaesthesia • Mar 27, 2019

Authors:

Abdella M. Habib

Andrei L. Okorokov

Matthew N. Hill

Abstract

The study of rare families with inherited pain insensitivity can identify new human-validated analgesic drug targets. Here, a 66-yr-old female presented with nil requirement for postoperative analgesia after a normally painful orthopaedic hand surgery (trapeziectomy). Further investigations revealed...

Subject

Fatty acid amide hydrolase

Anandamide

Palmitoylethanolamide

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