SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells

Sachs, Parysatis; Ding, Dong; Bergmaier, Philipp; Lamp, Boris; Schlagheck, Christina; Finkernagel, Florian; Nist, Andrea; Stiewe, Thorsten; E. Mermoud, Jacqueline

doi:10.1038/s41467-019-09078-0

Public

SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells

Published in Nature Communications • Mar 22, 2019

Authors:

Parysatis Sachs

Dong Ding

Philipp Bergmaier

Abstract

Endogenous retroviruses (ERVs) can confer benefits to their host but present a threat to genome integrity if not regulated correctly. Here we identify the SWI/SNF-like remodeler SMARCAD1 as a key factor in the control of ERVs in embryonic stem cells. SMARCAD1 is enriched at ERV subfamilies class I a...

Subject

Endogenous retrovirus

Retrotransposon

Chromatin

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