B cell maturation antigen–specific CAR T cells are clinically active in multiple myeloma

D. Cohen, Adam; L. Garfall, Alfred; A. Stadtmauer, Edward; Joseph Melenhorst, J.; F. Lacey, Simon; Lancaster, Eric; T. Vogl, Dan; M. Weiss, Brendan; Dengel, Karen; Nelson, Annemarie; Plesa, Gabriela; Chen, Fang; M. Davis, Megan; Hwang, Wei‐Ting; M. Young, Regina; L. Brogdon, Jennifer; Isaacs, Randi; Pruteanu-Malinici, Iulian; L. Siegel, Don; L. Levine, Bruce; H. June, Carl; C. Milone, Michael

doi:10.1172/jci126397

Public

B cell maturation antigen–specific CAR T cells are clinically active in multiple myeloma

Published in Journal of Clinical Investigation • Mar 21, 2019

Authors:

Adam D. Cohen

Alfred L. Garfall

Edward A. Stadtmauer

Abstract

BACKGROUND: Chimeric antigen receptor (CAR) T cells are a promising therapy for hematologic malignancies. B-cell maturation antigen (BCMA) is a rational target in multiple myeloma (MM). METHODS: We conducted a phase I study of autologous T cells lentivirally-transduced with a fully-human, BCMA-speci...

Subject

Multiple myeloma

Antigen

Chimeric antigen receptor

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