Dysregulation of kynurenine metabolism is related to proinflammatory cytokines, attention, and prefrontal cortex volume in schizophrenia

Kindler, Jochen; K. Lim, Chai; Shannon Weickert, Cynthia; Boerrigter, Danny; Galletly, Cherrie; Liu, Dennis; R. Jacobs, Kelly; Balzan, Ryan; Bruggemann, Jason; O׳Donnell, Maryanne; Lenroot, Rhoshel; J. Guillemin, Gilles; W. Weickert, Thomas

doi:10.1038/s41380-019-0401-9

Public

Dysregulation of kynurenine metabolism is related to proinflammatory cytokines, attention, and prefrontal cortex volume in schizophrenia

Published in Molecular Psychiatry • Apr 3, 2019

Authors:

Jochen Kindler

Chai K. Lim

Cynthia Shannon Weickert

Abstract

The kynurenine pathway (KP) of tryptophan (TRP) catabolism links immune system activation with neurotransmitter signaling. The KP metabolite kynurenic acid (KYNA) is increased in the brains of people with schizophrenia. We tested the extent to which: (1) brain KP enzyme mRNAs, (2) brain KP metabolit...

Subject

Kynurenine

Proinflammatory cytokine

Prefrontal cortex

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