CSF Free Light Chains as a Marker of Intrathecal Immunoglobulin Synthesis in Multiple Sclerosis: A Blood-CSF Barrier Related Evaluation in a Large Cohort

Şenel, Makbule; Mojib-Yezdani, Fatemeh; Braisch, Ulrike; Bachhuber, Franziska; Lewerenz, Jan; C. Ludolph, Albert; Otto, Markus; Tumani, Hayrettin

doi:10.3389/fimmu.2019.00641

Public

CSF Free Light Chains as a Marker of Intrathecal Immunoglobulin Synthesis in Multiple Sclerosis: A Blood-CSF Barrier Related Evaluation in a Large Cohort

Published in Frontiers in Immunology • Mar 29, 2019

Authors:

Makbule Şenel

Fatemeh Mojib-Yezdani

Ulrike Braisch

Abstract

Objectives: The importance of immunoglobulin G (IgG) oligoclonal bands (OCB) in the diagnosis of multiple sclerosis (MS) was reaffirmed again in the recently revised MS diagnostic criteria. Since OCB testing is based on non-quantitative techniques and demands considerable methodological experience, ...

Subject

Nephelometry

Intrathecal

Multiple sclerosis

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