Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets

Cassetta, Luca; Fragkogianni, Stamatina; H. Sims, Andrew; Swierczak, Agnieszka; M. Forrester, Lesley; Zhang, Hui; Soong, Daniel; Cotechini, Tiziana; Anur, Pavana; Y. Lin, Elaine; Fidanza, A; Lopez‐Yrigoyen, Martha; Millar, Michael; Urman, Alexandra; Ai, Zhichao; T. Spellman, Paul; Shelley Hwang, E.; Michael Dixon, J.; Wiechmann, Lisa; M. Coussens, Lisa; O. Smith, Harriet; W. Pollard, Jeffrey

doi:10.1016/j.ccell.2019.02.009

Public

Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets

Published in Cancer Cell • Mar 28, 2019

Authors:

Luca Cassetta

Stamatina Fragkogianni

Andrew H. Sims

Abstract

The roles of tumor-associated macrophages (TAMs) and circulating monocytes in human cancer are poorly understood. Here, we show that monocyte subpopulation distribution and transcriptomes are significantly altered by the presence of endometrial and breast cancer. Furthermore, TAMs from endometrial a...

Subject

Monocyte

Reprogramming

Macrophage

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