IL-7 receptor influences anti-TNF responsiveness and T cell gut homing in inflammatory bowel disease

Belarif, Lyssia; Danger, Richard; Kermarrec, Laëtitia; Nerrière‐Daguin, Véronique; Pengam, Sabrina; Durand, Tony; Mary, Caroline; Kerdreux, Elise; Gauttier, Vanessa; Kucik, Aneta; Thépenier, Virginie; Martin, J.P.; Chang, Christie; Rahman, Adeeb; Salabert, Nina; Braudeau, Cécile; Abidi, Ahmed; David, Grégoire; Malard, Florent; Takoudju, Céline; Martinet, Bernard; Gérard, Nathalie; Neveu, Isabelle; Neunlist, Michel; Coron, Emmanuel; T. MacDonald, Thomas; Desreumaux, Pierre; Mai, Hoa‐Le; Le Bas‐Bernardet, Stéphanie; Mosnier, Jean‐François; Mérad, Miriam; Josien, Régis; Brouard, Sophie; Soulillou, Jean‐Paul; Blancho, Gilles; Bourreille, Arnaud; Naveilhan, Philippe; Vanhove, Bernard; Poirier, Nicolas

doi:10.1172/jci121668

Public

IL-7 receptor influences anti-TNF responsiveness and T cell gut homing in inflammatory bowel disease

Published in Journal of Clinical Investigation • Apr 1, 2019

Authors:

Lyssia Belarif

Richard Danger

Laëtitia Kermarrec

Abstract

It remains unknown what causes inflammatory bowel disease (IBD), including signaling networks perpetuating chronic gastrointestinal inflammation in Crohn's disease (CD) and ulcerative colitis (UC), in humans. According to an analysis of up to 500 patients with IBD and 100 controls, we report that ke...

Subject

Inflammatory bowel disease

Immunology

Inflammation

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