PECAM-1 Stabilizes Blood-Brain Barrier Integrity and Favors Paracellular T-Cell Diapedesis Across the Blood-Brain Barrier During Neuroinflammation

Wimmer, Isabella; Tietz, Silvia; Nishihara, Hideaki; Deutsch, Urban; Sallusto, Federica; Gosselet, Fabien; Lyck, Ruth; A. Müller, William; Lassmann, Hans; Engelhardt, Britta

doi:10.3389/fimmu.2019.00711

Public

PECAM-1 Stabilizes Blood-Brain Barrier Integrity and Favors Paracellular T-Cell Diapedesis Across the Blood-Brain Barrier During Neuroinflammation

Published in Frontiers in Immunology • Apr 5, 2019

Authors:

Isabella Wimmer

Silvia Tietz

Hideaki Nishihara

Abstract

Breakdown of the blood-brain barrier (BBB) and increased immune cell trafficking into the central nervous system (CNS) are hallmarks of the pathogenesis of multiple sclerosis (MS). Platelet endothelial cell adhesion molecule-1 (PECAM-1; CD31) is expressed on cells of the vascular compartment and reg...

Subject

Paracellular transport

Blood–brain barrier

Cell biology

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