Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice

Zhao, Jiayi; Bi, Wei; Xiao, Shu; Lan, Xin; Cheng, Xiaofeng; Zhang, Jiawei; Lu, Daxiang; Wei, Wei; Wang, Yanping; Li, Hongmei; Fu, Yongmei; Zhu, Lihong

doi:10.1038/s41598-019-42286-8

Public

Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice

Published in Scientific Reports • Apr 8, 2019

Authors:

Jiayi Zhao

Wei Bi

Shu Xiao

Abstract

Abstract In this study, we investigated lipopolysaccharide (LPS)-induced cognitive impairment and neuroinflammation in C57BL/6J mice by using behavioral tests, immunofluorescence, enzyme-linked immunosorbent assay (ELISA) and Western blot. We found that LPS treatment leads to sickness behavior and c...

Subject

Neuroinflammation

Microglia

Western blot

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