Protein arginine methyltransferase 5: A novel therapeutic target for triple‐negative breast cancers

Vinet, Mathilde; Suresh, Samyuktha; Maire, Virginie; Monchecourt, Clarisse; Némati, Fariba; Lesage, Laëtitia; Pierre, Fabienne; Ye, Mengliang; Lescure, Auriane; Brisson, Amélie; Meseure, Didier; André, Nicolás; Rigaill, Guillem; Marangoni, Elisabetta; Del Nery, Elaine; Roman‐Roman, Sergio; Dubois, Thierry

doi:10.1002/cam4.2114

Public

Protein arginine methyltransferase 5: A novel therapeutic target for triple‐negative breast cancers

Published in Cancer Medicine • Apr 8, 2019

Authors:

Mathilde Vinet

Samyuktha Suresh

Virginie Maire

Abstract

TNBC is a highly heterogeneous and aggressive breast cancer subtype associated with high relapse rates, and for which no targeted therapy yet exists. Protein arginine methyltransferase 5 (PRMT5), an enzyme which catalyzes the methylation of arginines on histone and non-histone proteins, has recently...

Subject

Protein arginine methyltransferase 5

Triple-negative breast cancer

Cancer research

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