Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment

Dirkse, Anne; Golebiewska, Anna; Buder, Thomas; V. Nazarov, Petr; Muller, Arnaud; Poovathingal, Suresh; H. C. Brons, Nicolaas; Leite, Sónia; Sauvageot, Nicolas; Sarkisjan, Dzjemma; Seyfrid, Mathieu; Fritah, Sabrina; Stieber, Daniel; Michelucci, Alessandro; Hertel, Frank; Herold‐Mende, Christel; Azuaje, Francisco; Skupin, Alexander; Bjerkvig, Rolf; Deutsch, Andreas; Voß-Böhme, Anja; P. Niclou, Simone

doi:10.1038/s41467-019-09853-z

Public

Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment

Published in Nature Communications • Apr 16, 2019

Authors:

Anne Dirkse

Anna Golebiewska

Thomas Buder

Abstract

The identity and unique capacity of cancer stem cells (CSC) to drive tumor growth and resistance have been challenged in brain tumors. Here we report that cells expressing CSC-associated cell membrane markers in Glioblastoma (GBM) do not represent a clonal entity defined by distinct functional prope...

Subject

Cancer stem cell

Biology

Tumor microenvironment

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!