Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial

D Lyttle, Mark; Rainford, Naomi; Gamble, Carrol; Messahel, Shrouk; Humphreys, Amy; Hickey, Helen; Woolfall, Kerry; Roper, Louise; Noblet, Joanne; D. Lee, Elizabeth; Potter, Sarah; Tate, Paul; Iyer, Anand; Evans, Vicki; Appleton, Richard; Pereira, Matthew; Hardwick, Susie; Messahel, Shrouk; Noblet, Joanne; D Lee, Elizabeth; Greenwood-Bibby, Rachel; Buchanan, Mark; Lewis, Lucy; Hughes, Sharon; Hartshorn, Stuart; Rogers, Louise; Hopkins, Juliet; D Lyttle, Mark; Fernandez, Daphin; Potter, Sarah; R Lavigne-Smith, Holly; Moulsdale, Phoebe; Smith, Alice; Bingham, Tracey; N. Ross, James; Ramsey, Natasha; Hacking, Jo; Mullen, Niall; Corrigan, Paul; Prudhoe, S; Faza, Hani; Robinson, Gisela; Sunley, Rachel; Smith, Coral; Unsworth, Vanessa; Criddle, John; Laque, Martin; B Sheedy, Alyce; Anderson, Mark; M. Bell, Kathryn; Devine, Kirsty; Scott, Alex; Kumar, Ramesh; Armstrong, Sonia; Sutherland, Emer; Cantle, Fleur; Helyer, Sinead; Riozzi, Paul; Cotton, Hannah; Downes, Alice; Mollard, Helen; Roland, Damian; Hay, Felix; M. Gough, Christopher; Finucane, Sonya; Bevan, Catherine; Ramsay, Rebecca; Walton, Emily; Maney, Julie‐Ann; Dalzell, Elizabeth; Millar, Muriel; J Howells, R; Appelboam, Andy; Mackle, Daisy; G. Small, J.; Neil, Ashleigh; Choudhery, V.; MacLeod, Stewart; Browning, Jen; J. O’Neill, Thomas; Grahamslaw, Julia; Parikh, Ami; Skene, Imogen; Thomas, Rhys; Potier de la Morandiere, Katherine; L. Wilson, Jill; Danziger, Donna; Burke, Derek; Ramlakhan, Shammi; Evans, Jayne; Morcombe, Julie; Gormley, Stuart; Barling, Jason; Cathie, Katrina; Bayreuther, Jane; Ensom, Ruth; Iqbal, Yasser; Rounding, Sarah; Mulligan, Joanne; L. Bell, Claire; McLellan, Shona; Leighton, Shona; Sajjanhar, Tina; Nyirenda, Maggie; Crome, Laura; R. Williamson, Neil; Alcock, Anastasia; Edwards, Sara; R. Morgan, Jeffrey; Powell, Colin; A Ramesh, Chaniyil; Kamal-Uddin, Solomon; Linney, Mike; Vamvakiti, Katia; Floyd, Sharon; Hobden, Gill

doi:10.1016/s0140-6736(19)30724-x

Public

Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial

Published in The Lancet • Apr 17, 2019

Authors:

Mark D Lyttle

Naomi Rainford

Carrol Gamble

Abstract

BACKGROUND: Phenytoin is the recommended second-line intravenous anticonvulsant for treatment of paediatric convulsive status epilepticus in the UK; however, some evidence suggests that levetiracetam could be an effective and safer alternative. This trial compared the efficacy and safety of phenytoi...

Subject

Levetiracetam

Phenytoin

Medicine

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!