Cholangiocyte‐Derived Exosomal Long Noncoding RNA H19 Promotes Hepatic Stellate Cell Activation and Cholestatic Liver Fibrosis

Liu, Runping; Li, Xiaojiaoyang; Zhu, Weiwei; Wang, Yanyan; Zhao, Derrick; Wang, Xuan; C. Gurley, Emily; Liang, Guang; Chen, Weidong; Lai, Guan‐Hua; M. Pandak, William; Lippman, H; S. Bajaj, Jasmohan; B. Hylemon, Phillip; Zhou, Huiping

doi:10.1002/hep.30662

Public

Cholangiocyte‐Derived Exosomal Long Noncoding RNA H19 Promotes Hepatic Stellate Cell Activation and Cholestatic Liver Fibrosis

Published in Hepatology • Apr 15, 2019

Authors:

Runping Liu

Xiaojiaoyang Li

Weiwei Zhu

Abstract

Activation of hepatic stellate cells (HSCs) represents the primary driving force to promote the progression of chronic cholestatic liver diseases. We previously reported that cholangiocyte‐derived exosomal long noncoding RNA‐H19 (lncRNA‐H19) plays a critical role in promoting cholestatic liver injur...

Subject

Cholangiocyte

Hepatic stellate cell

Biology

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