Genetic Variants Associated With Cancer Therapy–Induced Cardiomyopathy

García‐Pavía, Pablo; Kim, Yuri; Alejandra Restrepo-Córdoba, María; G. Lunde, Ida; Wakimoto, Hiroko; M. Smith, Amanda; N. Toepfer, Christopher; Getz, Kelly; Gorham, Joshua; Patel, Parth; Ito, Kaoru; A. L. Willcox, Jon; Arany, Zoltàn; Li, Jian; Owens, Anjali; Govind, Risha; Núñez, Beatriz; Mazaika, Erica; Bayés‐Genís, Antoni; Walsh, Roddy; S. Finkelman, Brian; Lupón, Josep; Whiffin, Nicola; Serrano, Isabel; Midwinter, William; Wilk, Alicja; Bardajı́, Alfredo; Ingold, Nathan; Buchan, Rachel; Tayal, Upasana; A. Pascual‐Figal, Domingo; de Marvao, Antonio; Ahmad, Mian; Manuel García‐Pinilla, José; Pantazis, Antonis; Domínguez, Fernándo; John Baksi, A.; P. O’Regan, Declan; D. Rosen, Stuart; Prasad, Sanjay; Lara‐Pezzi, Enrique; Provencio, Mariano; R. Lyon, Alexander; Alonso‐Pulpón, Luis; A. Cook, Stuart; R. DePalma, Steven; J.R. Barton, Paul; Aplenc, Richard; G. Seidman, Jonathan; Ky, Bonnie; S. Ware, James; E. Seidman, Christine

doi:10.1161/circulationaha.118.037934

Public

Genetic Variants Associated With Cancer Therapy–Induced Cardiomyopathy

Published in Circulation • Apr 16, 2019

Authors:

Pablo García‐Pavía

Yuri Kim

María Alejandra Restrepo-Córdoba

Abstract

BACKGROUND: Cancer therapy-induced cardiomyopathy (CCM) is associated with cumulative drug exposures and preexisting cardiovascular disorders. These parameters incompletely account for substantial interindividual susceptibility to CCM. We hypothesized that rare variants in cardiomyopathy genes contr...

Subject

Medicine

Cardiomyopathy

Internal medicine

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