Checkpoint inhibitor therapy for cancer in solid organ transplantation recipients: an institutional experience and a systematic review of the literature

Abdel‐Wahab, Noha; Safa, Houssein; Abudayyeh, Ala; H. Johnson, Daniel; Anh Trinh, Van; M. Zobniw, Chrystia; Lin, Heather; K. Wong, Michael; Abdelrahim, Maen; Osama Gaber, A.; E. Suarez‐Almazor, María; Diab, Adi

doi:10.1186/s40425-019-0585-1

Public

Checkpoint inhibitor therapy for cancer in solid organ transplantation recipients: an institutional experience and a systematic review of the literature

Published in Journal for ImmunoTherapy of Cancer • Apr 16, 2019

Authors:

Noha Abdel‐Wahab

Houssein Safa

Ala Abudayyeh

Abstract

BACKGROUND: Checkpoint inhibitors (CPIs) have revolutionized the treatment of cancer, but their use remains limited by off-target inflammatory and immune-related adverse events. Solid organ transplantation (SOT) recipients have been excluded from clinical trials owing to concerns about alloimmunity,...

Subject

Medicine

Transplantation

Internal medicine

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