Immune tolerance in multiple sclerosis and neuromyelitis optica with peptide-loaded tolerogenic dendritic cells in a phase 1b trial

Zubizarreta, Irati; Flórez-Grau, Georgina; Vila, Gemma; Cabezón, Raquel; España, Carolina; Andorra, Magi; Saiz, Albert; Llufriu, Sara; Sepulveda, Maria; Sola-Valls, Nuria; H. Martinez-Lapiscina, Elena; Pulido-Valdeolivas, Irene; Casanova, Bonaventura; Martinez Gines, Marisa; Tellez, Nieves; Oreja-Guevara, Celia; Español, Marta; Trias, Esteve; Cid, Joan; Juan, Manel; Lozano, Miquel; Blanco, Yolanda; Steinman, Lawrence; Benitez-Ribas, Daniel; Villoslada, Pablo

doi:10.1073/pnas.1820039116

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Immune tolerance in multiple sclerosis and neuromyelitis optica with peptide-loaded tolerogenic dendritic cells in a phase 1b trial

Shared by NobleBlocks on Apr 8, 2019 • 12:00 AM UTC

Authors:

Irati Zubizarreta

Georgina Flórez-Grau

Gemma Vila

Abstract

Significance Application of antigen-specific immune tolerance in autoimmune disease is a long-sought goal. We studied diseases with abundant information on the autoimmune target: in multiple sclerosis (MS), various myelin antigens are known targets of T cells and antibodies, whereas in neuromyelitis...

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