TPP1 Delivery to Lysosomes with Extracellular Vesicles and their Enhanced Brain Distribution in the Animal Model of Batten Disease

J. Haney, Matthew; L. Klyachko, Natalia; B. Harrison, Emily; Zhao, Yuling; V. Kabanov, Alexander; V. Batrakova, Elena

doi:10.1002/adhm.201801271

Public

TPP1 Delivery to Lysosomes with Extracellular Vesicles and their Enhanced Brain Distribution in the Animal Model of Batten Disease

Published in Advanced Healthcare Materials • Apr 18, 2019

Authors:

Matthew J. Haney

Natalia L. Klyachko

Emily B. Harrison

Abstract

Extracellular vesicles (EVs) are promising natural nanocarriers for delivery of various types of therapeutics. Earlier engineered EV-based formulations for neurodegenerative diseases and cancer are reported. Herein, the use of macrophage-derived EVs for brain delivery of a soluble lysosomal enzyme t...

Subject

Batten disease

Transfection

Cell biology

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