Neurofilament as a potential biomarker for spinal muscular atrophy

T. Darras, Basil; O. Crawford, Thomas; S. Finkel, Richard; Mercuri, Eugenio; C. De Vivo, Darryl; Oskoui, Maryam; F. Tizzano, Eduardo; M. Ryan, Monique; Muntoni, Francesco; Zhao, Guolin; Staropoli, John; McCampbell, Alexander; Petrillo, Marco; Stebbins, Christopher; Fradette, Stephanie; Farwell, Wildon; J. Sumner, Charlotte

doi:10.1002/acn3.779

Public

Neurofilament as a potential biomarker for spinal muscular atrophy

Shared by NobleBlocks on Apr 17, 2019 • 12:00 AM UTC

Authors:

Basil T. Darras

Thomas O. Crawford

Richard S. Finkel

Abstract

Abstract Objective To evaluate plasma phosphorylated neurofilament heavy chain ( pNF ‐H) as a biomarker in spinal muscular atrophy ( SMA ). Methods Levels of pNF ‐H were measured using the ProteinSimple ® platform in plasma samples from infants with SMA enrolled in ENDEAR ( NCT 02193074) and infants...

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