Expression and clinical significance of PD-L1, B7-H3, B7-H4 and TILs in human small cell lung Cancer (SCLC)

Carvajal‐Hausdorf, Daniel; Altan, Mehmet; Velcheti, Vamsidhar; Gettinger, Scott; S. Herbst, Roy; L. Rimm, David; A. Schalper, Kurt

doi:10.1186/s40425-019-0540-1

Public

Expression and clinical significance of PD-L1, B7-H3, B7-H4 and TILs in human small cell lung Cancer (SCLC)

Published in Journal for ImmunoTherapy of Cancer • Mar 8, 2019

Authors:

Daniel Carvajal‐Hausdorf

Mehmet Altan

Vamsidhar Velcheti

Abstract

BACKGROUND: Small cell lung cancer (SCLC) accounts for 10-15% of all lung malignancies and its prognosis is dismal. Although early studies have shown promising clinical activity of immune checkpoint blockers, the immune composition and expression of potentially actionable immunostimulatory targets i...

Subject

Medicine

CD8

Lung cancer

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