Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

K. Küpers, Leanne; Monnereau, Claire; C. Sharp, Gemma; Yousefi, Paul; A. Salas, Lucas; Ghantous, Akram; M. Page, Christian; E. Reese, Sarah; J. Wilcox, Allen; Czamara, Darina; P. Starling, Anne; Novoloaca, Alexei; Lent, Samantha; Roy, Ritu; Hoyo, Cathrine; V. Breton, Carrie; Allard, Catherine; C. Just, Allan; M. Bakulski, Kelly; W. Holloway, John; M. Everson, Todd; Xu, Cheng‐Jian; Huang, Rae‐Chi; A. van der Plaat, Diana; Wielscher, Matthias; Kebede Merid, Simon; Ullemar, Vilhelmina; I. Rezwan, Faisal; Lahti, Jari; van Dongen, Jenny; A. S. Langie, Sabine; G. Richardson, Tom; C. Magnus, Maria; A. Nøhr, Ellen; Xu, Zongli; Duijts, Liesbeth; Zhao, Shanshan; Zhang, Weimin; Plusquin, Michelle; L. DeMeo, Dawn; Solomon, Olivia; H. Heimovaara, Joosje; D. Jima, Dereje; Gao, Lu; Bustamante, Mariona; Perron, Patrice; O. Wright, Robert; Hertz‐Picciotto, Irva; Zhang, Hongmei; R. Karagas, Margaret; Gehring, Ulrike; J. Marsit, Carmen; J. Beilin, Lawrence; M. Vonk, Judith; Järvelin, Marjo‐Riitta; Bergström, Anna; K. Örtqvist, Anne; Ewart, Susan; Villa, Pia; E. Moore, Sophie; Willemsen, Gonneke; Standaert, Arnout; E. Håberg, Siri; I. A. Sørensen, Thorkild; A. Taylor, Jack; Räikkönen, Katri; V. Yang, Ivana; Kechris, Katerina; S. Nawrot, Tim; J. Silver, Matt; Yun Gong, Yun; Richiardi, Lorenzo; Kogevinas, Manolis; A. Litonjua, Augusto; Eskenazi, Brenda; Huen, Karen; Mbarek, Hamdi; L. Maguire, Rachel; Dwyer, Terence; Vrijheid, Martine; Bouchard, Luigi; Baccarelli, Andrea; Croen, Lisa; Karmaus, Wilfried; Anderson, Denise; de Vries, Maaike; Sebért, Sylvain; Kere, Juha; Karlsson, Robert; Hasan Arshad, Syed; Hämäläinen, Esa; N. Routledge, Michael; I. Boomsma, Dorret; P. Feinberg, Andrew; J. Newschaffer, Craig; Govarts, Eva; Moisse, Matthieu; Daniele Fallin, M.; Melén, Erik; M. Prentice, Andrew; Kajantie, Eero; Almqvist, Catarina; Oken, Emily; Dabelea, Dana; Marike Boezen, H.; E. Melton, Phillip; J. Wright, Rosalind; H. Koppelman, Gerard; Trevisi, Letizia; Hivert, Marie‐France; Sunyer, Jordi; Cheng Munthe‐Kaas, Monica; K. Murphy, Susan; Corpeleijn, Eva; L. Wiemels, Joseph; Holland, Nina; Herceg, Zdenko; B. Binder, Elisabeth; Davey Smith, George; W. V. Jaddoe, Vincent; T. Lie, Rolv; Nystad, Wenche; J. London, Stephanie; A. Lawlor, Debbie; L. Relton, Caroline; Snieder, Harold; F. Felix, Janine

doi:10.1038/s41467-019-09671-3

Public

Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

Published in Nature Communications • Apr 23, 2019

Authors:

Leanne K. Küpers

Claire Monnereau

Gemma C. Sharp

Abstract

Abstract Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA ...

Subject

Epigenome

DNA methylation

Genetics

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