Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia

Paris, J; Morgan, Marcos; Campos, Joana; J. Spencer, Gary; Shmakova, Alena; Ivanova, Ivayla; Mapperley, Christopher; Lawson, Hannah; Wotherspoon, David; Sepúlveda, Catarina; Vukovic, Milica; Allen, Lewis; Sarapuu, Annika; Tavosanis, Andrea; V. Guitart, Amélie; Villacreces, Arnaud; Much, Christian; Choe, Junho; Azar, Ali; N. van de Lagemaat, Louie; Vernimmen, Douglas; Nehme, Ali; Mazurier, Frédéric; C. P. Somervaille, Tim; I. Gregory, Richard; O’Carroll, Dónal; R. Kranc, Kamil

doi:10.1016/j.stem.2019.03.021

Public

Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia

Published in Cell stem cell • Apr 25, 2019

Authors:

J Paris

Marcos Morgan

Joana Campos

Abstract

Acute myeloid leukemia (AML) is an aggressive clonal disorder of hematopoietic stem cells (HSCs) and primitive progenitors that blocks their myeloid differentiation, generating self-renewing leukemic stem cells (LSCs). Here, we show that the mRNA m 6 A reader YTHDF2 is overexpressed in a broad spect...

Subject

Biology

Haematopoiesis

Myeloid leukemia

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