PD-1 <sup>+</sup> regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer

Kamada, Takahiro; Togashi, Yosuke; Tay, Christopher; Ha, Danbee; Sasaki, Akinori; Nakamura, Yoshiaki; Sato, Eiichi; Fukuoka, Shota; Tada, Yasuko; Tanaka, Atsushi; Morikawa, Hiromasa; Kawazoe, Akihito; Kinoshita, Takahiro; Shitara, Kohei; Sakaguchi, Shimon; Nishikawa, Hiroyoshi

doi:10.1073/pnas.1822001116

Public

PD-1 + regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer

Published in Proceedings of the National Academy of Sciences • Apr 26, 2019

Authors:

Takahiro Kamada

Yosuke Togashi

Christopher Tay

Abstract

Significance PD-1 blockade is a cancer immunotherapy effective in various types of cancer. However, we observed rapid cancer progression, called hyperprogressive disease (HPD), in ∼10% of advanced gastric cancer patients treated with anti–PD-1 monoclonal antibody. Tumors of HPD patients possessed hi...

Subject

Blockade

Cancer

Cancer research

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