Single-Cell Transcriptomics Analyses of Neural Stem Cell Heterogeneity and Contextual Plasticity in a Zebrafish Brain Model of Amyloid Toxicity

İlyas Coşacak, Mehmet; Bhattarai, Prabesh; Reinhardt, Susanne; Petzold, A.; Dahl, Andreas; Zhang, Yixin; Kızıl, Çağhan

doi:10.1016/j.celrep.2019.03.090

Public

Single-Cell Transcriptomics Analyses of Neural Stem Cell Heterogeneity and Contextual Plasticity in a Zebrafish Brain Model of Amyloid Toxicity

Published in Cell Reports • Apr 1, 2019

Authors:

Mehmet İlyas Coşacak

Prabesh Bhattarai

Susanne Reinhardt

Abstract

The neural stem cell (NSC) reservoir can be harnessed for stem cell-based regenerative therapies. Zebrafish remarkably regenerate their brain by inducing NSC plasticity in a Amyloid-β-42 (Aβ42)-induced experimental Alzheimer's disease (AD) model. Interleukin-4 (IL-4) is also critical for AD-induced ...

Subject

Zebrafish

Transcriptome

Neuroscience

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