Preclinical Assessment of Leptin Transport into the Cerebrospinal Fluid in Diet‐Induced Obese Minipigs

Chmielewski, Alexandra; Hübert, Thomas; Descamps, Amandine; Mazur, Danièle; Daoudi, Mehdi; Ciofi, Philippe; Fontaine, C.; Caïazzo, Robert; Pattou, François; Prévot, Vincent; Pigeyre, Marie

doi:10.1002/oby.22465

Public

Preclinical Assessment of Leptin Transport into the Cerebrospinal Fluid in Diet‐Induced Obese Minipigs

Published in Obesity • Apr 21, 2019

Authors:

Alexandra Chmielewski

Thomas Hübert

Amandine Descamps

Abstract

OBJECTIVE: A minipig model was employed to explore the changes in endogenous leptin transport into the central nervous system and in hypothalamic sensitivity to exogenous leptin when individuals are placed on high-fat diet (HFD) compared with standard diet. METHODS: Serum and cerebrospinal fluid (CS...

Subject

Leptin

Internal medicine

Endocrinology

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