Efficacy and Safety Analysis of Nelipepimut-S Vaccine to Prevent Breast Cancer Recurrence: A Randomized, Multicenter, Phase III Clinical Trial

A. Mittendorf, Elizabeth; Lu, Biao; Melisko, Michelle; Price Hiller, Julie; Bondarenko, Igor; Murray Brunt, Adrian; Sergii, Grybach; Petrakova, Katarina; E. Peoples, George

doi:10.1158/1078-0432.ccr-18-2867

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Efficacy and Safety Analysis of Nelipepimut-S Vaccine to Prevent Breast Cancer Recurrence: A Randomized, Multicenter, Phase III Clinical Trial

Shared by NobleBlocks on Jul 15, 2019 • 12:00 AM UTC

Authors:

Elizabeth A. Mittendorf

Biao Lu

Michelle Melisko

Abstract

Abstract Purpose: In phase I/II studies, nelipepimut-S (NP-S) plus GM-CSF vaccine was well tolerated and effectively raised HER2-specific immunity in patients with breast cancer. Results from a prespecified interim analysis of a phase III trial assessing NP-S + GM-CSF are reported. Patients and Meth...

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