Defining mesenchymal stromal cell (MSC)‐derived small extracellular vesicles for therapeutic applications

W. Witwer, Kenneth; W. M. van Balkom, Bas; Bruno, Stefania; Choo, Andre; Dominici, Massimo; Gimona, Mario; F. Hill, Andrew; P.V. de Kleijn, Dominique; Koh, Mickey; Chai Lai, Ruenn; Alex Mitsialis, S.; A. Ortiz, Luis; Rohde, Eva; Asada, Takashi; Seong Toh, Wei; J. Weiss, Daniel; Zheng, Lei; Giebel, Bernd; Kiang Lim, Sai

doi:10.1080/20013078.2019.1609206

Public

Defining mesenchymal stromal cell (MSC)‐derived small extracellular vesicles for therapeutic applications

Published in Journal of Extracellular Vesicles • Apr 29, 2019

Authors:

Kenneth W. Witwer

Bas W. M. van Balkom

Stefania Bruno

Abstract

ABSTRACT Small extracellular vesicles (sEVs) from mesenchymal stromal/stem cells (MSCs) are transiting rapidly towards clinical applications. However, discrepancies and controversies about the biology, functions, and potency of MSC‐sEVs have arisen due to several factors: the diversity of MSCs and t...

Subject

Mesenchymal stem cell

Extracellular vesicles

Microvesicles

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