Inflammatory Breast Cancer Promotes Development of M2 Tumor-Associated Macrophages and Cancer Mesenchymal Cells through a Complex Chemokine Network

Valeta-Magara, Amanda; Gadi, Abhilash; Volta, Viviana; Walters, Beth; Arju, Rezina; Giashuddin, Shah; Zhong, Hua; J. Schneider, Robert

doi:10.1158/0008-5472.can-17-2158

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Inflammatory Breast Cancer Promotes Development of M2 Tumor-Associated Macrophages and Cancer Mesenchymal Cells through a Complex Chemokine Network

Shared by NobleBlocks on Jul 1, 2019 • 12:00 AM UTC

Authors:

Amanda Valeta-Magara

Abhilash Gadi

Viviana Volta

Abstract

Abstract Inflammatory breast cancer (IBC) is a highly aggressive form of breast cancer that displays profound cancer stem cell (CSC) and mesenchymal features that promote rapid metastasis. Another hallmark of IBC is high infiltration of M2 tumor-associated (immune-suppressing) macrophages. The molec...

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