Association of Intrathecal Immunoglobulin G Synthesis With Disability Worsening in Multiple Sclerosis

Gasperi, Christiane; Salmen, Anke; Antony, Gisela; Bayas, Antonios; Heesen, Christoph; Kümpfel, Tania; A. Linker, Ralf; Paul, Friedemann; Stangel, Martin; Tackenberg, Björn; Then Bergh, Florian; Warnke, Clemens; Weber, Frank; Wiendl, Heinz; Wildemann, Brigitte; K. Zettl, Uwe; Ziemann, Ulf; Zipp, Frauke; Tumani, Hayrettin; Gold, Ralf; Hemmer, Bernhard; the German Competence Network of Multiple Sclerosis, for

doi:10.1001/jamaneurol.2019.0905

Public

Association of Intrathecal Immunoglobulin G Synthesis With Disability Worsening in Multiple Sclerosis

Published in JAMA Neurology • Apr 30, 2019

Authors:

Christiane Gasperi

Anke Salmen

Gisela Antony

Abstract

Importance: Reliable biomarkers associated with disability worsening in multiple sclerosis (MS) are still needed. Objective: To determine a possible association of intrathecal IgG synthesis and early disability worsening as measured by Expanded Disability Status Scale (EDSS) scoring in patients with...

Subject

Multiple sclerosis

Intrathecal

Antibody

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