Cannabinoid Attenuation of Intestinal Inflammation in Chronic SIV-Infected Rhesus Macaques Involves T Cell Modulation and Differential Expression of Micro-RNAs and Pro-inflammatory Genes

Kumar, Vinay; Torben, Workineh; Mansfield, Joshua; Álvarez, Xavier; Vande Stouwe, Curtis; Li, Jian; N. Byrareddy, Siddappa; J. Didier, Peter; Pahar, Bapi; E. Molina, Patricia; Mohan, Mahesh

doi:10.3389/fimmu.2019.00914

Public

Cannabinoid Attenuation of Intestinal Inflammation in Chronic SIV-Infected Rhesus Macaques Involves T Cell Modulation and Differential Expression of Micro-RNAs and Pro-inflammatory Genes

Published in Frontiers in Immunology • Apr 30, 2019

Authors:

Vinay Kumar

Workineh Torben

Joshua Mansfield

Abstract

Cannabis use is frequent in HIV-infected individuals for its appetite stimulation and anti-inflammatory effects. To identify the underlying molecular mechanisms associated with these effects, we simultaneously profiled micro-RNA (miRNA) and mRNA expression in the colon of chronically simian immunode...

Subject

Simian immunodeficiency virus

Proinflammatory cytokine

Immunology

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