Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis

A. Widjaja, Anissa; Kumar Singh, Brijesh; Adami, Eleonora; Viswanathan, Sivakumar; Dong, Jinrui; D’Agostino, Giuseppe; Ng, Benjamin; Lim, Wei‐Wen; Tan, Jessie; Paleja, Bhairav; Tripathi, Madhulika; Yun Lim, Sze; G. Shekeran, Shamini; Chothani, Sonia; Rabes, Anne; Sombetzki, Martina; Bruinstroop, Eveline; Pei Min, Lio; A. Sinha, Rohit; Albani, Salvatore; M. Yen, Paul; Schäfer, Sebastian; A. Cook, Stuart

doi:10.1053/j.gastro.2019.05.002

Public

Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis

Published in Gastroenterology • May 9, 2019

Authors:

Anissa A. Widjaja

Brijesh Kumar Singh

Eleonora Adami

Abstract

Background & Aims We studied the role of interleukin 11 (IL11) signaling in the pathogenesis of nonalcoholic steatohepatitis (NASH) using hepatic stellate cells (HSCs), hepatocytes, and mouse models of NASH. Methods We stimulated mouse and human fibroblasts, HSCs, or hepatocytes with IL11 and other ...

Subject

Steatohepatitis

Steatosis

Hepatocyte

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