Analysis of Plasma Cell-Free DNA by Ultradeep Sequencing in Patients With Stages I to III Colorectal Cancer

Reinert, Thomas; Vesterman Henriksen, Tenna; Christensen, Emil; Sharma, Shruti; Salari, Raheleh; Sethi, Himanshu; Knudsen, Michael; Nordentoft, Iver; Wu, Hsin-Ta; Tin, Antony; H. Rasmussen, Mads; Vang, Søren; Shchegrova, Svetlana; Frydendahl, Amanda; Srinivasan, Ramya; J. Assaf, Zoe; Balcioglu, Mustafa; Olson, Alexander; Dashner, Scott; Hafez, Dina; Navarro, Samantha; Goel, Shruti; Rabinowitz, Matthew; R. Billings, Paul; Sigurjonsson, Styrmir; Dyrskjøt, Lars; Swenerton, Ryan; Aleshin, Alexey; Laurberg, Søren; Husted Madsen, Anders; Kannerup, Anne-Sofie; Stribolt, Katrine; Palmelund Krag, Søren; Hjerrild Iversen, Lene; Andersson Gotschalck, Kåre; Jimmy Lin, Cheng-Ho; Zimmermann, Bernhard; L. Andersen, Claus

doi:10.1001/jamaoncol.2019.0528

Public

Analysis of Plasma Cell-Free DNA by Ultradeep Sequencing in Patients With Stages I to III Colorectal Cancer

Published in JAMA Oncology • May 9, 2019

Authors:

Thomas Reinert

Tenna Vesterman Henriksen

Emil Christensen

Abstract

IMPORTANCE: Novel sensitive methods for detection and monitoring of residual disease can improve postoperative risk stratification with implications for patient selection for adjuvant chemotherapy (ACT), ACT duration, intensity of radiologic surveillance, and, ultimately, outcome for patients with c...

Subject

Medicine

Colorectal cancer

Oncology

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