Association analyses identify 31 new risk loci for colorectal cancer susceptibility

Law, Philip; Timofeeva, Maria; Fernández–Rozadilla, Ceres; Broderick, Peter; B. Studd, James; Fernández‐Tajes, Juan; M. Farrington, Susan; Svinti, Victoria; Palles, Claire; Orlando, Giulia; Sud, Amit; Holroyd, Amy; Penegar, Steven; Τheodoratou, Evropi; G Vaughan-Shaw, P; Campbell, Harry; Zgaga, Lina; Hayward, Caroline; Campbell, Archie; E. Harris, Sarah; J. Deary, Ian; M. Starr, John; Gatcombe, Laura; Pinna, Maria; Briggs, Sarah; Martin, Lynn; Jaeger, Emma; Sharma‐Oates, Archana; E. East, James; J. Leedham, Simon; Arnold, Roland; Johnstone, Elaine; Wang, Haitao; Kerr, David; Kerr, Rachel; Maughan, Tim; Kaplan, Richard; Al Tassan, Nada; Palin, Kimmo; A. Hänninen, Ulrika; Cajuso, Tatiana; Tanskanen, Tomas; Kondelin, Johanna; Kaasinen, Eevi; Sarin, Antti‐Pekka; G. Eriksson, Johan; Rissanen, Harri; Knekt, Paul; Pukkala, ­Eero; Jousilahti, Pekka; Salomaa, Veikko; Ripatti, Samuli; Palotie, Aarno; Renkonen‐Sinisalo, Laura; Lepistö, Anna; Böhm, J.; Mecklin, Jukka‐Pekka; D. Buchanan, Daniel; Ko Win, Aung; L. Hopper, John; A. Jenkins, Mark; M. Lindor, Noralane; A. Newcomb, Polly; Gallinger, Steven; Duggan, David; Casey, Graham; Hoffmann, Per; M. Nöthen, Markus; Jöckel, Karl‐Heinz; F. Easton, Douglas; D.P. Pharoah, Paul; Peto, Julian; Canzian, Federico; J. Swerdlow, Anthony; A. Eeles, Rosalind; Kote‐Jarai, Zsofia; Muir, Kenneth; Pashayan, Nora; E. Henderson, Brian; A. Haiman, Christopher; R. Schumacher, Fredrick; Amin Al Olama, Ali; Benlloch, Sara; I. Berndt, Sonja; V. Conti, David; Wiklund, Fredrik; J. Chanock, Stephen; M. Gapstur, Susan; L. Stevens, Victoria; M. Tangen, Catherine; Batra, Jyotsna; A. Clements, Judith; Grönberg, Henrik; Schleutker, Johanna; Albanes, Demetrius; Wolk, Alicja; West, Catharine; A. Mucci, Lorelei; Cancel‐Tassin, Géraldine; Koutros, Stella; D. Sørensen, Karina; Marie Grindedal, Eli; E. Neal, David; C. Hamdy, Freddie; Donovan, Jenny; C. Travis, Ruth; J. Hamilton, Robert; A. Ingles, Sue; S. Rosenstein, Barry; Lu, Yong‐Jie; G. Giles, Graham; S. Kibel, Adam; Vega, Ana; Kogevinas, Manolis; L. Penney, Kathryn; Y. Park, Jong; L. Stanford, Janet; Cybulski, Cezary; G. Nordestgaard, Børge; Maier, Christiane; Kim, Jeri; M. John, Esther; R. Teixeira, Manuel; L. Neuhausen, Susan; De Ruyck, Kim; Hassan Abdul Razack, Azad; F. Newcomb, Lisa; Gamulin, Marija; Kaneva, Radka; Usmani, Nawaid; Claessens, Frank; A. Townsend, Paul; Gago-Domínguez, Manuela; J. Roobol, Monique; Ménégaux, F.; Khaw, Kay‐Tee; Cannon‐Albright, Lisa; Pandha, Hardev; N. Thibodeau, Stephen; Harkin, Andrea; Allan, Karen; McQueen, John; Paul, James; Iveson, Timothy; Saunders, Mark; Butterbach, Katja; Chang‐Claude, Jenny; Hoffmeister, Michael; Brenner, Hermann; Kirac, Iva; Matošević, Petar; Hofer, Philipp; Brezina, Stefanie; Gsur, Andrea; P. Cheadle, Jeremy; A. Aaltonen, Lauri; Tomlinson, Ian; S. Houlston, Richard; G. Dunlop, Malcolm

doi:10.1038/s41467-019-09775-w

Public

Association analyses identify 31 new risk loci for colorectal cancer susceptibility

Published in Nature Communications • May 14, 2019

Authors:

Philip Law

Maria Timofeeva

Ceres Fernández–Rozadilla

Abstract

Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that identifies SNPs at 31 new CRC risk loci. We also identify eight independent r...

Subject

Colorectal cancer

Genome-wide association study

Genetics

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