Circular RNA AKT3 upregulates PIK3R1 to enhance cisplatin resistance in gastric cancer via miR-198 suppression

Huang, Xiaoxu; Li, Zheng; Zhang, Qiang; Wang, Weizhi; Li, Bowen; Wang, Lu; Xu, Zhipeng; Xu, Zhipeng; Zeng, Ailiang; Zhang, Xuan; Zhang, Xuan; He, Zhongyuan; Li, Qiang; Sun, Guangli; Wang, Sen; Li, Qing; Zhang, Lu; Zhang, Lu; Xu, Zekuan; Xu, Zekuan; Xu, Zekuan

doi:10.1186/s12943-019-0969-3

Public

Circular RNA AKT3 upregulates PIK3R1 to enhance cisplatin resistance in gastric cancer via miR-198 suppression

Published in Molecular Cancer • Mar 30, 2019

Authors:

Xiaoxu Huang

Zheng Li

Qiang Zhang

Abstract

BACKGROUND: Cisplatin (CDDP) treatment is one of the most predominant chemotherapeutic strategies for patients with gastric cancer (GC). A better understanding of the mechanisms of CDDP resistance can greatly improve therapeutic efficacy in patients with GC. Circular RNAs (circRNAs) are a class of n...

Subject

Biology

Cisplatin

Cancer research

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