Genomic correlates of clinical outcome in advanced prostate cancer

Abida, Wassim; Cyrta, Joanna; Heller, Glenn; Prandi, Davide; Armenia, Joshua; Coleman, Ilsa; Cieslik, Marcin; Benelli, Matteo; Robinson, Dan; M. Van Allen, Eliezer; Sboner, Andrea; Fedrizzi, Tarcisio; Miguel Mosquera, Juan; D. Robinson, Brian; De Sarkar, Navonil; P. Kunju, Lakshmi; Tomlins, Scott; Mi Wu, Yi; Nava Rodrigues, Daniel; Loda, Massimo; Gopalan, Anuradha; E. Reuter, Victor; C. Pritchard, Colin; Mateo, Joaquin; Bianchini, Diletta; Miranda, Susana; Carreira, Suzanne; Rescigno, Pasquale; Filipenko, Julie; Vinson, Jacob; B. Montgomery, Robert; Beltran, Himisha; I. Heath, Elisabeth; I. Scher, Howard; W. Kantoff, Philip; Taplin, Mary-Ellen; Schultz, Nikolaus; S. deBono, Johann; Demichelis, Francesca; S. Nelson, Peter; A. Rubin, Mark; M. Chinnaiyan, Arul; L. Sawyers, Charles

doi:10.1073/pnas.1902651116

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Genomic correlates of clinical outcome in advanced prostate cancer

Shared by NobleBlocks on May 6, 2019 • 12:00 AM UTC

Authors:

Wassim Abida

Joanna Cyrta

Glenn Heller

Abstract

Heterogeneity in the genomic landscape of metastatic prostate cancer has become apparent through several comprehensive profiling efforts, but little is known about the impact of this heterogeneity on clinical outcome. Here, we report comprehensive genomic and transcriptomic analysis of 429 patients ...

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