Genomic correlates of clinical outcome in advanced prostate cancer

Abida, Wassim; Cyrta, Joanna; Heller, Glenn; Prandi, Davide; Armenia, Joshua; M. Coleman, Ilsa; Cieślik, Marcin; Benelli, Matteo; R. Robinson, Dan; M. Van Allen, Eliezer; Sboner, Andrea; Fedrizzi, Tarcisio; Miguel Mosquera, Juan; D. Robinson, Brian; De Sarkar, Navonil; P. Kunju, Lakshmi; A. Tomlins, Scott; Mi Wu, Yi; Nava Rodrigues, Daniel; Loda, Massimo; Gopalan, Anuradha; E. Reuter, Victor; C. Pritchard, Colin; Mateo, Joaquı́n; Bianchini, Diletta; Miranda, Susana; Carreira, Suzanne; Rescigno, Pasquale; Filipenko, Julie; Vinson, Jacob; Montgomery, Bruce; Beltran, Himisha; I. Heath, Elisabeth; I. Scher, Howard; W. Kantoff, Philip; Taplin, Mary‐Ellen; Schultz, Nikolaus; S. de Bono, Johann; Demichelis, Francesca; S. Nelson, Peter; A. Rubin, Mark; M. Chinnaiyan, Arul; L. Sawyers, Charles

doi:10.1073/pnas.1902651116

Public

Genomic correlates of clinical outcome in advanced prostate cancer

Published in Proceedings of the National Academy of Sciences • May 6, 2019

Authors:

Wassim Abida

Joanna Cyrta

Glenn Heller

Abstract

Heterogeneity in the genomic landscape of metastatic prostate cancer has become apparent through several comprehensive profiling efforts, but little is known about the impact of this heterogeneity on clinical outcome. Here, we report comprehensive genomic and transcriptomic analysis of 429 patients ...

Subject

Enzalutamide

Prostate cancer

Androgen receptor

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