ESMO recommendations on microsatellite instability testing for immunotherapy in cancer, and its relationship with PD-1/PD-L1 expression and tumour mutational burden: a systematic review-based approach

Luchini, Claudio; Bibeau, Frédéric; Ligtenberg, M.; Singh, Naveena; Nottegar, Alessia; Bosse, Tjalling; E. Miller, Robert; Riaz, Nadeem; Douillard, J-Y; André, Fabrice; Scarpa, Aldo

doi:10.1093/annonc/mdz116

Public

ESMO recommendations on microsatellite instability testing for immunotherapy in cancer, and its relationship with PD-1/PD-L1 expression and tumour mutational burden: a systematic review-based approach

Published in Annals of Oncology • Mar 29, 2019

Authors:

Claudio Luchini

Frédéric Bibeau

M. Ligtenberg

Abstract

BACKGROUND: Cancers with a defective DNA mismatch repair (dMMR) system contain thousands of mutations most frequently located in monomorphic microsatellites and are thereby defined as having microsatellite instability (MSI). Therefore, MSI is a marker of dMMR. MSI/dMMR can be identified using immuno...

Subject

Microsatellite instability

MSH6

MSH2

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