Molecular Mechanisms Responsible for Therapeutic Potential of Mesenchymal Stem Cell-Derived Secretome

Randall Harrell, Carl; Fellabaum, Crissy; Jovičić, Nemanja; Djonov, Valentin; Arsenijević, Nebojša; Volarević, Vladislav

doi:10.3390/cells8050467

Public

Molecular Mechanisms Responsible for Therapeutic Potential of Mesenchymal Stem Cell-Derived Secretome

Published in Cells • May 16, 2019

Authors:

Carl Randall Harrell

Crissy Fellabaum

Nemanja Jovičić

Abstract

Mesenchymal stem cell (MSC)-sourced secretome, defined as the set of MSC-derived bioactive factors (soluble proteins, nucleic acids, lipids and extracellular vesicles), showed therapeutic effects similar to those observed after transplantation of MSCs. MSC-derived secretome may bypass many side effe...

Subject

Mesenchymal stem cell

Transplantation

Regeneration (biology)

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