Free light chains in the cerebrospinal fluid. Comparison of different methods to determine intrathecal synthesis

Hegen, Harald; Walde, Janette; Milosavljevic, Dejan; Aboulenein-Djamshidian, Fahmy; Şenel, Makbule; Tumani, Hayrettin; Deisenhammer, Florian; Presslauer, Stefan

doi:10.1515/cclm-2018-1300

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Free light chains in the cerebrospinal fluid. Comparison of different methods to determine intrathecal synthesis

Published in Clinical Chemistry and Laboratory Medicine (CCLM) • May 21, 2019

Authors:

Harald Hegen

Janette Walde

Dejan Milosavljevic

Abstract

Background Free light chains (FLC) have been proposed as diagnostic biomarkers in the cerebrospinal fluid (CSF) of patients with inflammatory central nervous system (CNS) diseases. However, which method to use for determining an intrathecal FLC synthesis has not yet been clarified. The objective of ...

Subject

Nephelometry

Cerebrospinal fluid

Intrathecal

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