Rapid Clearance Profile of Plasma Circulating Tumor HPV Type 16 DNA during Chemoradiotherapy Correlates with Disease Control in HPV-Associated Oropharyngeal Cancer

S. Chera, Bhishamjit; Kumar, Sunil; T. Beaty, Brian; Marron, David; R. Jefferys, Stuart; Green, Rebecca; C. Goldman, Emily; J. Amdur, Robert; Sheets, Nathan; Dagan, Roi; Neil Hayes, D.; Weiss, Jared; E. Grilley‐Olson, Juneko; M. Zanation, Adam; Hackman, Trevor; M. Blumberg, Jeffrey; Patel, Samip; C. Weissler, Mark; Tan, Xianming; S. Parker, Joel; M. Mendenhall, William; P. Gupta, Gaorav

doi:10.1158/1078-0432.ccr-19-0211

Public

Rapid Clearance Profile of Plasma Circulating Tumor HPV Type 16 DNA during Chemoradiotherapy Correlates with Disease Control in HPV-Associated Oropharyngeal Cancer

Published in Clinical Cancer Research • May 14, 2019

Authors:

Bhishamjit S. Chera

Sunil Kumar

Brian T. Beaty

Abstract

Abstract Purpose: To identify a profile of circulating tumor human papilloma virus (HPV) DNA (ctHPVDNA) clearance kinetics that is associated with disease control after chemoradiotherapy (CRT) for HPV-associated oropharyngeal squamous cell carcinoma (OPSCC). Experimental Design: A multi-institutiona...

Subject

Circulating tumor DNA

Medicine

Chemoradiotherapy

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