Activation of unliganded FGF receptor by extracellular phosphate potentiates proteolytic protection of FGF23 by its O-glycosylation

Takashi, Yuichi; Kosako, Hidetaka; Sawatsubashi, Shun; Kinoshita, Yuka; Ito, Nobuaki; Tsoumpra, M.K.; Nangaku, Masaomi; Abe, Masahiro; Matsuhisa, Munehide; Kato, Shigeaki; Matsumoto, Toshio; Fukumoto, Seiji

doi:10.1073/pnas.1815166116

Public

Activation of unliganded FGF receptor by extracellular phosphate potentiates proteolytic protection of FGF23 by its O-glycosylation

Published in Proceedings of the National Academy of Sciences • May 16, 2019

Authors:

Yuichi Takashi

Hidetaka Kosako

Shun Sawatsubashi

Abstract

Fibroblast growth factor (FGF) 23 produced by bone is a hormone that decreases serum phosphate (Pi). Reflecting its central role in Pi control, serum FGF23 is tightly regulated by serum Pi alterations. FGF23 levels are regulated by the transcriptional event and posttranslational cleavage into inacti...

Subject

Fibroblast growth factor

Fibroblast growth factor receptor 1

Fibroblast growth factor 23

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