Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway

Lee, Yu-Ru; Chen, Ming; D. Lee, Jonathan; Zhang, Jinfang; Lin, Shu‐Yu; Fu, Tian‐Min; Chen, Hao; Ishikawa, T.; Chiang, Shang-Yin; Katon, Jesse; Zhang, Yang; V. Shulga, Yulia; C. Bester, Assaf; Fung, Jacqueline; Monteleone, Emanuele; Wan, Lixin; Shen, Chen; Hsu, Chih-Hung; Papa, Antonella; G. Clohessy, John; Teruya‐Feldstein, Julie; Kumar Jain, Suresh; Wu, Hao; E. Matesic, Lydia; Chen, Ruey‐Hwa; Wei, Wenyi; Paolo Pandolfi, Pier

doi:10.1126/science.aau0159

Public

Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway

Published in Science • May 16, 2019

Authors:

Yu-Ru Lee

Ming Chen

Jonathan D. Lee

Abstract

Supporting tumor suppression The protein PTEN is a phosphatase and tumor suppressor whose activity is often decreased in human cancers. Thus, reactivating such a protein could potentially be an effective therapy against cancer. Lee et al. identified a ubiquitin E3 ligase (WWP1) as a PTEN-interacting...

Subject

PTEN

Ubiquitin ligase

Cancer research

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