Extending thrombolysis to 4·5–9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data

Campbell, Bruce; Ma, Henry; A. Ringleb, Peter; Parsons, Mark; Churilov, Leonid; Bendszus, Martin; Levi, Christopher; Hsu, Chung; Kleinig, Timothy; Fatar, Marc; Leys, Didier; A. Molina, Carlos; Wijeratne, Tissa; Curtze, Sami; M. Dewey, Helen; Alan Barber, P.; Butcher, Kenneth; Anne De Silva, Deidre; F. Bladin, Christopher; Yassi, Nawaf; Pfaff, Johannes; Sharma, Gagan; Bivard, Andrew; Desmond, Patricia; Schwab, Stefan; D. Schellinger, Peter; Yan, Bernard; Mitchell, Peter; Serena, Joaquı́n; Toni, Danilo; Thijs, Vincent; Hacke, Werner; M. Davis, Stephen; A. Donnan, Geoffrey; A. Donnan, Geoffrey; M. Davis, Stephen; Ma, Henry; Campbell, Bruce; Churilov, Leonid; Parsons, Mark; Yan, Bernard; Mitchell, Peter; Yassi, Nawaf; Sharma, Gagan; Desmond, Patricia; J. Oxley, Thomas; Y. Wu, Teddy; Shah, Darshan; Zhao, Henry; Rodrigues, Edrich; Salvaris, Patrick; Alemseged, Fana; Ng, Felix; Williams, Cameron; Ng, Jo-Lyn; T.H. Tu, Hans; McDonald, Amy; M. Jackson, David; Tsoleridis, Jessica; McCoy, Rachael; Pesavento, Lauren; Weir, Louise; Bivard, Andrew; Kleinig, Timothy; R. Patel, Sanjay; Harvey, Jackson; Mahadevan, Jeyaledchumy; Cheong, EunSun; Balabanski, Anna; F. Waters, Michael; Drew, Roy; Cranefield, Jennifer; Wijeratne, Tissa; A. Mackey, Elizabeth; Celestino, Sherisse; Low, Essie; M. Dewey, Helen; F. Bladin, Christopher; Sien Loh, Poh; Choi, Philip; Coote, Skye; Frost, Tanya; B. Hogan, Kyla; Ding, Cheng; McModie, S.; Zhang, W.W.; Kyndt, Christopher; Moore, Alan; Ross, Zofia; Edward Liu, Jack; Miteff, Ferdinand; Levi, Christopher; Ang, Timothy; J. Spratt, Neil; García-Esperón, Carlos; Kaauwai, Lara; G. Phan, Thanh; Ly, John; Singhal, Shaloo; Clissold, Benjamin; Wong, Kitty; Krause, Martín; Day, Susan; Sturm, Jonathan; O'Brian, Bill; Grimley, Rohan; Thijs, Vincent; Simpson, Marion; Lee-Archer, Matthew; Brodtmann, Amy; Coulton, Bronwyn; Young, Dennis; Wong, Andrew; Muller, Claire; Field, Deborah; Vallat, Wilson; Maxwell, Vanessa; Bailey, Peter; Sabet, Arman; Mishra, Sachin; H. Tan, Meng; George, Kola; Alan Barber, P.; Zhao, Lin‐Bo; Meretoja, Atte; Curtze, Sami; Tatlisumak, Turgut; Sibolt, Gerli; Tiainen, Marjaana; Koivu, Matti; Aarnio, Karolinaa; J. Virta, Jyri; Kasari, O.; Eirola, S.; Sun, Mu-Chien; Chen, T.C.; Chuang, Chia‐Hui; Chen, Y.Y.; Lin, C.M.; Ho, S; Hsiao, Pi-Ju; Tsai, Cho-Jen; Huang, Wenguo; Yang, Dongyuan; Huang, H.-Y.; Wang, W.C.; Liu, Cindy; Lu, Mengxin; Lu, Cheng‐Hsien; Kung, W.L.; Jiang, Shou-Feng; Wu, Yun‐Cheng; Huang, Shiyu; Tseng, Chun; Tseng, Liang‐Wei; Guo, Yongchun; Lin, Ding-lai; Hsu, Chao-Wen; Kuan, C.W.; Hsu, Jia‐Shuo; Tsai, Hsin‐Chi; Suzuki, Motofumi; Sun, Yameng; Chen, HongJie; Lu, Chi‐Ju; Lin, Chun-Jen; Huang, C.C.; J. Chu, H.; Lee, C.Y.; Chang, Warren; Lo, Yu‐Chun; Hsu, Yueh‐Han; Chen, Chung‐Hwan; Sung, Pi‐Shan; Ysai, C.L.; Jeng, Jiann‐Shing; Tang, Sung‐Chun; Tsai, Li‐Kai; Yeh, Shin‐Joe; Lee, Y.C.; Wang, Y.T.; Chung, T.C.; Hu, Chaur‐Jong; Yiu Chan, Lok; Chiou, Yu‐Wei; Lien, Li-Ming; Yeh, Hsu-Ling; Yeh, Jen-Hao; Chen, W.H.; Lan Lau, Chee; Marie Chang, Anna; Lee, I.Y.; Huang, M.Y.; Lee, J.T.; Peng, G.S.; C. Lim, Jeremy; Hsu, Yi‐Cheng; Lin, Chao; Cheng, C.A.; Yen, Chia‐Hung; Yang, Fang; Hsu, Chiun; Sung, Yueh‐Feng; Tsai, Chia‐Kuang; Tsai, Chia-Lung; Hsiao, Pi-Ju; Lee, A.; J. Hankey, Graeme; Blacker, David; Gerraty, Richard; Chen, Chun‐I; Hsu, C-S.; S. Cowley, Elise; McCoy, Rachael; Sallaberger, Michele; Snow, Barry; Kolbe, John; Stark, R.; T. King, John; Macdonnell, Richard; Attia, John; D’Este, Catherine; Bernhardt, Julie; M. Carey, Leeanne; A. Cadilhac, Dominique; S. Anderson, Craig; W. Howells, David; Alan Barber, P.; Connelly, Alan; Macleod, Malcolm; O’Collins, Victoria; Wilson, W.J.; Macaulay, Lisa; Bendszus, Martin; Bluhmki, Erich; Eschenfelder, Christoph; Hacke, Werner; A. Molina, Carlos; Leys, Didier; A. Ringleb, Peter; D. Schellinger, Peter; Schwab, Stefan; Toni, Danilo; Wahlgren, Nils; M. Wardlaw, Joanna; Oppenheim, Catherine; R. Lees, Kennedy; Kaste, Markku; von Kummer, Rüdiger; Châtellier, Gilles; Laage, Rico; Nuñez, Xavier; Ehrenkrona, Christina; Svenson, Ann-Sofie; Cove, Lynda; Niederkorn, Kurt; Gruber, Franz; Kapeller, Peter; Mikulík, Robert; Mas, Jean‐Louis; Berrouschot, Jörg; Sobesky, Jan; Köhrmann, Martin; Steiner, Thorsten; Kessler, Christof; Fatar, Marc; Dziewas, Rainer; Poli, Sven; Althaus-Knaurer, Katharina; Bovi, Paolo; Luna Rodríguez, Alain; F. Arenillas, Juan; W. Muir, Keith; Veltkamp, Roland; Dixit, Anand; Muddegowda, Girish; Kala, Lalit; Anne De Silva, Deidre; Butcher, Kenneth; Byrnes, Graham; Peeters, André; B. Chalk, Jonathan; Fink, John; Kimber, Thomas; Schultz, David; J. Hand, Peter; Frayne, Judith; M. Tress, Brian; J. McNeil, John; J. Burns, Rachel; Johnston, Claiborne; Williams, M.L.

doi:10.1016/s0140-6736(19)31053-0

Public

Extending thrombolysis to 4·5–9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data

Published in The Lancet • May 22, 2019

Authors:

Bruce Campbell

Henry Ma

Peter A. Ringleb

Abstract

BACKGROUND: Stroke thrombolysis with alteplase is currently recommended 0-4·5 h after stroke onset. We aimed to determine whether perfusion imaging can identify patients with salvageable brain tissue with symptoms 4·5 h or more from stroke onset or with symptoms on waking who might benefit from thro...

Subject

Thrombolysis

Meta-analysis

Medicine

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