Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

Genomics Platform, Broad; Flannick, Jason; , CHARGE; , LuCamp; , ProDiGY; , GoT2D; , ESP; , SIGMA-T2D; , T2D-GENES; , AMP-T2D-GENES; M. Mercader, Josep; Fuchsberger, Christian; S. Udler, Miriam; Mahajan, Anubha; Wessel, Jennifer; M. Teslovich, Tanya; Caulkins, Lizz; Koesterer, Ryan; Barajas‐Olmos, Francisco; W. Blackwell, Thomas; Boerwinkle, Eric; A. Brody, Jennifer; Centeno-Cruz, Federico; Ling, Chen; Chen, Siying; Contreras-Cubas, Cecilia; J. Córdova, Emilio; Correa, Adolfo; L. Cortés, Maria; A. DeFronzo, Ralph; M. Dolan, Lawrence; L. Drews, Kimberly; Elliott, Amanda; S. Floyd, James; Gabriel, Stacey; Eugenia Garay-Sevilla, María; Garcia‐Ortíz, Humberto; Gross, Myron; Han, Sohee; L. Heard‐Costa, Nancy; Jackson, Anne; E. Jørgensen, Marit; Min Kang, Hyun; M. Kelsey, Megan; Kim, Bong-Jo; A. Koistinen, Heikki; Kuusisto, Johanna; B. Leader, Joseph; Linneberg, Allan; Liu, Ching‐Ti; Liu, Jianjun; Lyssenko, Valeriya; K. Manning, Alisa; Marcketta, Anthony; Manuel Malacara-Hernández, Juan; Martínez‐Hernández, Angélica; Matsuo, Karen; J. Mayer‐Davis, Elizabeth; Mendoza‐Caamal, Elvia; L. Mohlke, Karen; C. Morrison, Alanna; Ndungu, Anne; Ng, Maggie; O’Dushlaine, Colm; J. Payne, A.; Pihoker, Catherine; S. Post, Wendy; Preuß, Michael; M. Psaty, Bruce; S. Vasan, Ramachandran; William Rayner, N.; P. Reiner, Alexander; Revilla, M.; R. Robertson, Neil; Santoro, Nicola; Schurmann, Claudia; Yee So, Wing; Soberón, Xavier; M. Stringham, Heather; M. Strom, Tim; H. T. Tam, Claudia; Thameem, Farook; Tomlinson, Brian; Torres, Jason; P. Tracy, Russell; M. van Dam, Rob; Vujković, Marijana; Wang, Shuai; Welch, Ryan; R. Witte, Daniel; Yin Wong, Tien; Atzmon, Gil; Barzilai, Nir; Blangero, John; L. Bonnycastle, Lori; W. Bowden, Donald; C. Chambers, John; Chan, Edmund; Cheng, Ching‐Yu; Shin Cho, Yoon; S. Collins, Francis; S. de Vries, Paul; Duggirala, Ravindranath; Gläser, Benjamin; González, Clicerio; Elena Gonzalez, Ma; Groop, Leif; S. Kooner, Jaspal; Heon Kwak, Soo; Laakso, Markku; M. Lehman, Donna; M. Nilsson, Peter; D. Spector, Timothy; Shyong Tai, E; Tuomi, Tiinamaija; Tuomilehto, Jaakko; G. Wilson, James; A. Aguilar‐Salinas, Carlos; Böttinger, Erwin; Burke, Brian; J. Carey, David; C.N. Chan, Juliana; Dupuis, Josée; Frossard, Philippe; R. Heckbert, Susan; Yeong Hwang, Mi; Jin Kim, Young; Lester Kirchner, H.; Lee, Jong‐Young; Lee, Juyoung; J. F. Loos, Ruth; C.W., Ronald; D. Morris, Andrew; J. O’Donnell, Christopher; N. A. Palmer, Colin; S. Pankow, James; Soo Park, Kyong; Rasheed, Asif; Saleheen, Danish; Sim, Xueling; S. Small, Kerrin; Ying Teo, Yik; A. Haiman, Christopher; L. Hanis, Craig; E. Henderson, Brian; Orozco, Lorena; Tusié‐Luna, Teresa; E. Dewey, Frederick; Baras, Aris; Gieger, Christian; Meitinger, Thomas; Strauch, Konstantin; A. Lange, Leslie; Grarup, Niels; Hansen, Torben; Pedersen, Oluf; Zeitler, Philip; Dabelea, Dana; R. Abecasis, Gonçalo; I. Bell, Graeme; J. Cox, Nancy; Seielstad, Mark; Sladek, Robert; B. Meigs, James; S. Rich, Steve; I. Rotter, Jerome; Altshuler, David; P. Burtt, Noël; J. Scott, Laura; P. Morris, Andrew; C. Florez, José; I. McCarthy, Mark; Boehnke, Michael

doi:10.1038/s41586-019-1231-2

Public

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

Published in Nature • May 22, 2019

Authors:

Broad Genomics Platform

Jason Flannick

CHARGE

Abstract

Protein-coding genetic variants that strongly affect disease risk can yield relevant clues to disease pathogenesis. Here we report exome-sequencing analyses of 20,791 individuals with type 2 diabetes (T2D) and 24,440 non-diabetic control participants from 5 ancestries. We identify gene-level associa...

Subject

Exome sequencing

Type 2 diabetes

Exome

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!