Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy

Vincent, Jean‐Louis; François, Bruno; Б. Заболотских, И.; Kumar Daga, Mradul; Lascarrou, Jean-Baptiste; Yu. Кirov, М.; Pettilä, Ville; Wittebole, Xavier; Meziani, Ferhat; Mercier, Emmanuelle; Margareth Lobo, Suzana; S. Barie, Philip; Crowther, Mark; T. Esmon, Charles; Fareed, Jawed; Gando, Satoshi; J. Gorelick, Kenneth; Levi, Marcel; Mira, Jean-Paul; M. Opal, Steven; E. Parrillo, Joseph; A. Russell, James; Saito, Hidehiko; Tsuruta, Kazuhisa; Sakai, Takumi; Fineberg, David; the SCARLET Trial Group, for

doi:10.1001/jama.2019.5358

Public

Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy

Published in JAMA • May 19, 2019

Authors:

Jean‐Louis Vincent

Bruno François

И. Б. Заболотских

Abstract

Importance: Previous research suggested that soluble human recombinant thrombomodulin may reduce mortality among patients with sepsis-associated coagulopathy. Objective: To determine the effect of human recombinant thrombomodulin vs placebo on 28-day all-cause mortality among patients with sepsis-as...

Subject

Medicine

Coagulopathy

Thrombomodulin

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