Hyaluronidase with pH‐responsive Dextran Modification as an Adjuvant Nanomedicine for Enhanced Photodynamic‐Immunotherapy of Cancer

Wang, Hairong; Han, Xiao; Dong, Ziliang; Xu, Jun; Wang, Jianwen; Liu, Zhuang

doi:10.1002/adfm.201902440

Public

Hyaluronidase with pH‐responsive Dextran Modification as an Adjuvant Nanomedicine for Enhanced Photodynamic‐Immunotherapy of Cancer

Published in Advanced Functional Materials • May 22, 2019

Authors:

Hairong Wang

Xiao Han

Ziliang Dong

Abstract

Abstract The condensed tumor extracellular matrix (ECM) consisting of cross‐linked hyaluronic acid (HA) is one of key factors that results in the aberrant tumor microenvironment (TME) and the resistance to various types of therapies. Herein, hyaluronidase (HAase) is modified by a biocompatible polym...

Subject

Nanomedicine

Tumor microenvironment

Photodynamic therapy

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