Randomized Phase II Trial of Chemoradiotherapy Plus Induction or Consolidation Chemotherapy as Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer: CAO/ARO/AIO-12

Fokas, Emmanouil; Allgäuer, Michael; Polat, Bülent; Klautke, Günther; G. Grabenbauer, Gerhard; Fietkau, Rainer; Kuhnt, Thomas; Staib, Ludger; Brunner, Thomas; Grosu, Anca‐Ligia; Schmiegel, Wolff; Jacobasch, Lutz; Weitz, Jürgen; Folprecht, Gunnar; Schlenska‐Lange, Anke; Flentje, Michael; Germer, Christoph‐Thomas; Grützmann, Robert; Schwarzbach, Matthias; Paolucci, Vittorio; O. Bechstein, Wolf; Friede, Tim; Ghadimi, Michael; Hofheinz, Ralf‐Dieter; Rödel, Claus; behalf of the German Rectal Cancer Study Group, on

doi:10.1200/jco.19.00308

Public

Randomized Phase II Trial of Chemoradiotherapy Plus Induction or Consolidation Chemotherapy as Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer: CAO/ARO/AIO-12

Published in Journal of Clinical Oncology • May 31, 2019

Authors:

Emmanouil Fokas

Michael Allgäuer

Bülent Polat

Abstract

PURPOSE Total neoadjuvant therapy is a new paradigm for rectal cancer treatment. Optimal scheduling of preoperative chemoradiotherapy (CRT) and chemotherapy remains to be established. PATIENTS AND METHODS We conducted a multicenter, randomized, phase II trial using a pick-the-winner design on the ba...

Subject

Medicine

Oxaliplatin

Fluorouracil

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