Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes

Wang, Heming; M. Lane, Jacqueline; E. Jones, Samuel; S. Dashti, Hassan; M. Ollila, Hanna; R. Wood, Andrew; T. van Hees, Vincent; Brumpton, Ben; S. Winsvold, Bendik; Kantojärvi, Katri; Palviainen, Teemu; E. Cade, Brian; Sofer, Tamar; Song, Yanwei; Patel, Krunal; Anderson, Simon; A. Bechtold, David; Bowden, Jack; Emsley, Richard; D. Kyle, Simon; A. Little, Max; Loudon, Andrew; A. J. L. Scheer, Frank; Purcell, Shaun; C. Richmond, Rebecca; Spiegelhalder, Kai; Tyrrell, Jessica; Zhu, Xiaofeng; Hublin, Christer; Kaprio, Jaakko; Kristiansson, Kati; Sulkava, Sonja; Paunio, Tiina; Hveem, Kristian; B. Nielsen, Jonas; J. Willer, Cristen; Zwart, John‐Anker; Beate Strand, Linn; M. Frayling, Timothy; Ray, David; A. Lawlor, Debbie; K. Rutter, Martin; N. Weedon, Michael; Redline, Susan; Saxena, Richa

doi:10.1038/s41467-019-11456-7

Public

Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes

Published in Nature Communications • Aug 13, 2019

Authors:

Heming Wang

Jacqueline M. Lane

Samuel E. Jones

Abstract

Excessive daytime sleepiness (EDS) affects 10-20% of the population and is associated with substantial functional deficits. Here, we identify 42 loci for self-reported daytime sleepiness in GWAS of 452,071 individuals from the UK Biobank, with enrichment for genes expressed in brain tissues and in n...

Subject

Chronotype

Excessive daytime sleepiness

Single-nucleotide polymorphism

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