A catalog of genetic loci associated with kidney function from analyses of a million individuals

Cohort Study, Lifelines; Wuttke, Matthias; A. Million Veteran Program, V.; Li, Yong; Li, Man; B. Sieber, Karsten; F. Feitosa, Mary; Gorski, Mathias; Tin, Adrienne; Wang, Lihua; Y. Chu, Audrey; Hoppmann, Anselm; Kirsten, Holger; Giri, Ayush; Fang Chai, Jin; Sveinbjörnsson, Garðar; O. Tayo, Bamidele; Nutile, Teresa; Fuchsberger, Christian; Marten, Jonathan; Cocca, Massimiliano; Ghasemi, Sahar; Xu, Yizhe; Horn, Katrin; Noce, Damia; J. van der Most, Peter; Sedaghat, Sanaz; Yu, Zhi; Akiyama, Masato; Afaq, Saima; S. Ahluwalia, Tarunveer; Almgren, Peter; Amin, Najaf; Ärnlöv, Johan; J. L. Bakker, Stephan; Bansal, Nisha; Baptista, Daniela; Bergmann, Sven; L. Biggs, Mary; Biino, Ginevra; Boehnke, Michael; Boerwinkle, Eric; Boissel, Mathilde; P. Böttinger, Erwin; Boutin, Thibaud; Brenner, Hermann; Brumat, Marco; Burkhardt, Ralph; S. Butterworth, Adam; Campana, Eric; Campbell, Archie; Campbell, Harry; Canouil, Mickaël; J. Carroll, Robert; Catamo, Eulalia; C. Chambers, John; Chee, Miao-Ling; Chee, Miao-Li; Chen, Xu; Cheng, Ching‐Yu; Cheng, Yurong; Christensen, Kaare; Cífková, Renata; Ciullo, Marina; Pina Concas, Maria; P. Cook, James; Coresh, Josef; Corre, Tanguy; Sala, Cinzia; Cusi, Daniele; Danesh, John; Warwick Daw, E.; H. de Borst, Martin; De Grandi, Alessandro; de Mutsert, Renée; P. J. de Vries, Aiko; Degenhardt, Frauke; Delgado, Graciela; Demirkan, Ayşe; Di Angelantonio, Emanuele; Dittrich, Katalin; Divers, Jasmin; Dorajoo, Rajkumar; Eckardt, Kai‐Uwe; Ehret, Georg; Elliott, Paul; Endlich, Karlhans; K. Evans, Michele; F. Felix, Janine; Hui Xian Foo, Valencia; H. Franco, Oscar; Franke, André; I. Freedman, Barry; Freitag‐Wolf, Sandra; Friedlander, Yechiel; Froguel, Philippe; T. Gansevoort, Ron; Gao, He; Gasparini, Paolo; Michael Gaziano, J.; Giedraitis, Vilmantas; Gieger, Christian; Girotto, Giorgia; Giulianini, Franco; Gögele, Martin; D. Gordon, Scott; F. Guðbjartsson, Daníel; Guðnason, Vilmundur; Haller, Toomas; Hamet, Pavel; B. Harris, Tamara; A. Hartman, Catharina; Hayward, Caroline; N. Hellwege, Jacklyn; Heng, Chew‐Kiat; A. Hicks, Andrew; Hofer, Edith; Huang, Wei; Hutri‐Kähönen, Nina; Hwang, Shih‐Jen; Arfan Ikram, M.; S. Indridason, Ólafur; Ingelsson, Erik; Ising, Marcus; W. V. Jaddoe, Vincent; Jakobsdóttir, Jóhanna; B. Jonas, Jost; K. Joshi, Peter; Shilpa Josyula, Navya; Jung, Bettina; Kähönen, Mika; Kamatani, Yoichiro; M. Kammerer, Candace; Kanai, Masahiro; Kastarinen, Mika; M. Kerr, Shona; Chuen Khor, Chiea; Kieß, Wieland; E. Kleber, Marcus; Köenig, Wolfgang; S. Kooner, Jaspal; Körner, Antje; Kovács, Péter; T. Kraja, Aldi; Krajčoviechová, Alena; Kramer, Holly; K. Krämer, Bernhard; Kronenberg, Florian; Kubo, Michiaki; Kühnel, Brigitte; Kuokkanen, Mikko; Kuusisto, Johanna; La Bianca, Martina; Laakso, Markku; A. Lange, Leslie; D. Langefeld, Carl; Jen-Mai Lee, Jeannette; Lehne, Benjamin; Lehtimäki, Terho; Lieb, Wolfgang; M. L. Lim, S.; Lind, Lars; M. Lindgren, Cecilia; Liu, Jun; Liu, Jianjun; Loeffler, Markus; J. F. Loos, Ruth; Lucae, Susanne; Ann Lukas, Mary; Lyytikäinen, Leo‐Pekka; Mägi, Reedik; K. E. Magnusson, Patrik; Mahajan, Anubha; G. Martin, Nicholas; Martins, Jade; März, Winfried; Mascalzoni, Deborah; Matsuda, Koichi; Meisinger, Christa; Meitinger, Thomas; Melander, Olle; Metspalu, Andres; Mikaelsdottir, Evgenia; Milaneschi, Yuri; Miliku, Kozeta; P. Mishra, Pashupati; L. Mohlke, Karen; Mononen, Nina; W. Montgomery, Grant; O. Mook‐Kanamori, Dennis; C. Mychaleckyj, Josyf; N. Nadkarni, Girish; A. Nalls, Mike; Nauck, Matthias; Nikus, Kjell; Ning, Boting; M. Nolte, Ilja; Noordam, Raymond; R. O’Connell, Jeffrey; L. O’Donoghue, Michelle; Ólafsson, Ísleifur; J. Oldehinkel, Albertine; Orho‐Melander, Marju; H. Ouwehand, Willem; Padmanabhan, Sandosh; D. Palmer, Nicholette; Pálsson, Runólfur; W.J.H. Penninx, Brenda; T. Perls, Thomas; Perola, Markus; Pirastu, Mario; Pirastu, Nicola; Pistis, Giorgio; Podgornaia, Anna; Polašek, Ozren; Ponte, Belén; J. Porteous, David; Poulain, Tanja; P. Pramstaller, Peter; Preuß, Michael; P. Prins, Bram; A. Province, Michael; J. Rabelink, Ton; M. Raffield, Laura; T. Raitakari, Olli; F. Reilly, Dermot; Rettig, Rainer; Rheinberger, Myriam; Rice, Kenneth; M. Ridker, Paul; Rivadeneira, Fernando; Rizzi, Federica; J. Roberts, David; Robino, Antonietta; Rossing, Peter; Rudan, Igor; Rueedi, Rico; Ruggiero, Daniela; A. Ryan, Kathleen; Saba, Yasaman; Sabanayagam, Charumathi; Salomaa, Veikko; Salvi, Erika; Saum, Kai‐Uwe; Schmidt, Helena; Schmidt, Reinhold; Schöttker, Ben; Schulz, Christina‐Alexandra; Schupf, Nicole; M. Shaffer, Christian; Shi, Yuan; V. Smith, Albert; H. Smith, Blair; Soranzo, Nicole; N. Spracklen, Cassandra; Strauch, Konstantin; M. Stringham, Heather; Stümvoll, Michael; Svensson, Per; Szymczak, Silke; Shyong Tai, E; M. Tajuddin, Salman; Tan, Nicholas; D. Taylor, Kent; Teren, Andrej; Chung Tham, Yih; Thiery, Joachim; H. L. Thio, Chris; Thomsen, Hauke; Þorleifsson, Guðmar; Toniolo, Daniela; Tönjes, Anke; Tremblay, Johanne; Tzoulaki, Ioanna; G. Uitterlinden, André; Vaccargiu, Simona; M. van Dam, Rob; van der Harst, Pim; M. van Duijn, Cornelia; Edward, D; Verweij, Niek; Vogelezang, Suzanne; Völker, Uwe; Vollenweider, Péter; Waeber, Gérard; Waldenberger, Mélanie; Wallentin, Lars; Xing Wang, Ya; Wang, Chaolong; Waterworth, Dawn; Bin Wei, Wen; D. White, Harvey; B. Whitfield, John; H. Wild, Sarah; F. Wilson, James; K. Wojczynski, Mary; Wong, Charlene; Yin Wong, Tien; Xu, Liang; Yang, Qiong; Yasuda, Masayuki; M. Yerges-Armstrong, Laura; Zhang, Weihua; B. Zonderman, Alan; I. Rotter, Jerome; Bochud, Murielle; M. Psaty, Bruce; Vitart, Véronique; G. Wilson, James; Dehghan, Abbas; Parsa, Afshin; I. Chasman, Daniel; Ho, Kevin; P. Morris, Andrew; Devuyst, Olivier; Akilesh, Shreeram; A. Pendergrass, Sarah; Sim, Xueling; A. Böger, Carsten; Okada, Yukinori; L. Edwards, Todd; Snieder, Harold; Stefánsson, Kāri; M. Hung, Adriana; M. Heid, Iris; Scholz, Markus; Teumer, Alexander; Köttgen, Anna; Pattaro, Cristian

doi:10.1038/s41588-019-0407-x

Public

A catalog of genetic loci associated with kidney function from analyses of a million individuals

Published in Nature Genetics • May 31, 2019

Authors:

Lifelines Cohort Study

Matthias Wuttke

V. A. Million Veteran Program

Abstract

Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through trans-ancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated l...

Subject

Biology

Genetics

Evolutionary biology

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!